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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
Enciso-Mora, Victor; Broderick, Peter; Ma, Yussanne; Jarrett, Ruth F; Hjalgrim, Henrik; Hemminki, Kari; van den Berg, Anke; Olver, Bianca; Lloyd, Amy; Dobbins, Sara E; Lightfoot, Tracy; van Leeuwen, Flora E; Försti, Asta; Diepstra, Arjan; Broeks, Annegien; Vijayakrishnan, Jayaram; Shield, Lesley; Lake, Annette; Montgomery, Dorothy; Roman, Eve; Engert, Andreas; von Strandmann, Elke Pogge; Reiners, Katrin S; Nolte, Ilja M; Smedby, Karin E; Adami, Hans-Olov; Russell, Nicola S; Glimelius, Bengt; Hamilton-Dutoit, Stephen; de Bruin, Marieke; Ryder, Lars P; Molin, Daniel; Sorensen, Karina Meden; Chang, Ellen T; Taylor, Malcolm; Cooke, Rosie; Hofstra, Robert; Westers, Helga; van Wezel, Tom; van Eijk, Ronald; Ashworth, Alan; Rostgaard, Klaus; Melbye, Mads; Swerdlow, Anthony J; Houlston, Richard S.
Afiliação
  • Enciso-Mora V; Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • Broderick P; Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • Ma Y; Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • Jarrett RF; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
  • Hjalgrim H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Hemminki K; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
  • van den Berg A; Department of Pathology & Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Olver B; Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • Lloyd A; Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • Dobbins SE; Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • Lightfoot T; Epidemiology & Genetics Unit, Department of Health Sciences, University of York, York, YO10 5DD, UK.
  • van Leeuwen FE; Department of Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
  • Försti A; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
  • Diepstra A; Department of Pathology & Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Broeks A; Department of Experimental Therapy, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
  • Vijayakrishnan J; Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • Shield L; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
  • Lake A; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
  • Montgomery D; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
  • Roman E; Epidemiology & Genetics Unit, Department of Health Sciences, University of York, York, YO10 5DD, UK.
  • Engert A; University Hospital of Cologne, Department of Internal Medicine, Cologne, Germany.
  • von Strandmann EP; University Hospital of Cologne, Department of Internal Medicine, Cologne, Germany.
  • Reiners KS; University Hospital of Cologne, Department of Internal Medicine, Cologne, Germany.
  • Nolte IM; Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Centre Groningen, University of Groningen, the Netherlands.
  • Smedby KE; Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.
  • Adami HO; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • Russell NS; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
  • Glimelius B; Department of Radiotherapy, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
  • Hamilton-Dutoit S; Department of Pathology and Oncology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • de Bruin M; Department of Oncology, Radiology and Clinical Immunology, Uppsala University, SE-751 85, Uppsala, Sweden.
  • Ryder LP; Institute of Pathology, Aarhus University Hospital, DK-8000, Aarhus, Denmark.
  • Molin D; Department of Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
  • Sorensen KM; Department of Clinical Immunology, University Hospital of Copenhagen, Rigshospitalet, DK-2100, Copenhagen, Denmark.
  • Chang ET; Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden.
  • Taylor M; Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark.
  • Cooke R; Cancer Prevention Institute of California, Fremont, CA 94538.
  • Hofstra R; Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Westers H; Cancer Immunogenetics Group, School of Cancer & Enabling Sciences, University of Manchester, Research Floor, St Mary's Hospital, Manchester, M13 9WL, UK.
  • van Wezel T; Section of Epidemiology, Institute of Cancer Research, Sutton, SM2 5NG, UK.
  • van Eijk R; Department of Genetics University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Ashworth A; Department of Genetics University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Rostgaard K; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
  • Melbye M; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
  • Swerdlow AJ; The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
  • Houlston RS; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Nat Genet ; 42(12): 1126-1130, 2010 Dec.
Article em En | MEDLINE | ID: mdl-21037568
ABSTRACT
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Cromossomos Humanos / Predisposição Genética para Doença / Proteínas Proto-Oncogênicas c-rel / Fator de Transcrição GATA3 / Estudo de Associação Genômica Ampla / Loci Gênicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Reino Unido
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Cromossomos Humanos / Predisposição Genética para Doença / Proteínas Proto-Oncogênicas c-rel / Fator de Transcrição GATA3 / Estudo de Associação Genômica Ampla / Loci Gênicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Reino Unido