Vascular calcification in chronic renal failure: what have we learned from animal studies?
Circ Res
; 108(2): 249-64, 2011 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-21252152
ABSTRACT
Accelerated atherosclerotic plaque calcification and extensive medial calcifications are common and highly detrimental complications of chronic kidney disease. Valid murine models have been developed to investigate both pathologically distinguishable complications, which allow for better insight into the cellular mechanisms underlying these vascular pathologies and evaluation of compounds that might prevent or retard the onset or progression of vascular calcification. This review describes various experimental models that have been used for the study of arterial intimal and/or medial calcification and discusses the extent to which this experimental research has contributed to our current understanding of vascular calcification, particularly in the setting of chronic renal failure.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Calcinose
/
Sistema Cardiovascular
/
Falência Renal Crônica
Limite:
Animals
Idioma:
En
Revista:
Circ Res
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Bélgica