Relative concentrations of haemostatic factors and cytokines in solvent/detergent-treated and fresh-frozen plasma.
Br J Anaesth
; 106(4): 505-11, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21310721
ABSTRACT
BACKGROUND:
Indications, efficacy, and safety of plasma products are highly debated. We compared the concentrations of haemostatic proteins and cytokines in solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP).METHODS:
Concentrations of the following parameters were measured in 25 SDP and FFP samples fibrinogen (FBG), factor (F) II, F V, F VII, F VIII, F IX, F X, F XIII, von Willebrand factor (vWF), D-Dimers, ADAMTS-13 protease, tumour necrosis factor-α (TNF-α), interleukin (IL)-1ß, IL-6, IL-8, and IL-10.RESULTS:
Mean FBG concentrations in SDP and FFP were similar, but in FFP, the range was larger than in SDP (P<0.01). Mean F II, F VII, F VIII, F IX, and F XIII levels did not differ significantly. Higher concentrations of F V (P<0.01), F X (P<0.05), vWF (P<0.01), and ADAMTS-13 (P<0.01) were found in FFP. With the exception of F VIII and F IX, the range of concentrations for all of these factors was smaller (P<0.05) in SDP than in FFP. Concentrations of TNF-α, IL-8, and IL-10 (all P<0.01) were higher in FFP than in SDP, again with a higher variability and thus larger ranges (P<0.01).CONCLUSIONS:
Coagulation factor content is similar for SDP and FFP, with notable exceptions of less F V, vWF, and ADAMTS-13 in SDP. Cytokine concentrations (TNFα, IL-8, and IL-10) were significantly higher in FFP. The clinical relevance of these findings needs to be established in outcome studies.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Plasma
/
Solventes
/
Fatores de Coagulação Sanguínea
/
Citocinas
/
Detergentes
Limite:
Humans
Idioma:
En
Revista:
Br J Anaesth
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Suíça