Production of H2S by 3-mercaptopyruvate sulphurtransferase.
J Biochem
; 149(4): 357-9, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21324981
ABSTRACT
Hydrogen sulfide (H(2)S) has been established as the third gaseous signaling molecule following nitric oxide and carbon monoxide and participates in a variety of cellular functions such as modulation of neuronal transmission, endothelium-dependent vasorelaxation, stimulation of angiogenesis and regulation of insulin release. Although cystathionine ß-synthase and cystathionine γ-lyase have been regarded as the main producers of H(2)S in many tissues including brain, liver and kidney, Kimura and his colleagues have recently communicated that 3-mercaptopyruvate sulphurtransferase coupled with cysteine (aspartate) aminotransferase is responsible for the production of H(2)S in the vascular endothelium of the thoracic aorta [Shibuya et al. (2009) J. Biochem. 146, 623-626]. This finding provides a new insight into the production of the physiologically important signaling molecule.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Sulfurtransferases
/
Endotélio Vascular
/
Sulfeto de Hidrogênio
Limite:
Animals
Idioma:
En
Revista:
J Biochem
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão