Prognostic significance of Wnt-1, ß-catenin and E-cadherin expression in advanced colorectal carcinoma.

ABSTRACT

Wnt/ß-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, ß-catenin and Wnt-1 proteins in colorectal tumors. Expression of ß-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, ß-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear ß-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/ß-catenin pathway plays an important role in advanced colorectal carcinoma.