Prognostic significance of Wnt-1, ß-catenin and E-cadherin expression in advanced colorectal carcinoma.
Pathol Oncol Res
; 17(4): 955-63, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21678109
ABSTRACT
Wnt/ß-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, ß-catenin and Wnt-1 proteins in colorectal tumors. Expression of ß-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, ß-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear ß-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/ß-catenin pathway plays an important role in advanced colorectal carcinoma.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Colon_e_reto
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Caderinas
/
Proteína Wnt1
/
Beta Catenina
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pathol Oncol Res
Assunto da revista:
NEOPLASIAS
/
PATOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Polônia