Effects of thiopental, pentobarbital, and ketamine on endothelin-induced constriction of porcine cerebral arteries.
Anesthesiology
; 72(5): 939-41, 1990 May.
Article
em En
| MEDLINE
| ID: mdl-2187378
ABSTRACT
Contractile mechanisms of endothelin, a newly isolated vasoactive substance from endothelium, were evaluated in anterior cerebral arteries (ACA). Furthermore, the effects of thiopental, pentobarbital, ketamine, and diltiazem on the endothelin-induced cerebral vasoconstriction were also studied. Endothelin induced cerebral arterial contractions in concentrations above 3 X 10(-10) M. The median effective concentration (ED50 X10(-9) M) of endothelin was 2.1 +/- 0.7 (n = 6). Endothelin did not elicit contractions in preparations soaked in Ca2(+)-free solution, but addition of 2.5 mM Ca2+ to the baths induced marked contractions. Thiopental and pentobarbital attenuated endothelin-induced contractions at concentrations above 3 X 10(4) M, while ketamine was effective above 10(-3) M. In contrast, diltiazem decreased endothelin-induced vasoconstriction at 10(-6) M. The findings suggest that endothelin may cause contractions of porcine cerebral arteries by influx of Ca2+ through Ca2+ channels. The cerebral vasomotion induced by endothelin, however, does not seem to be influenced by clinical doses of barbiturates and ketamine.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Pentobarbital
/
Peptídeos
/
Tiopental
/
Vasoconstrição
/
Artérias Cerebrais
/
Ketamina
Limite:
Animals
Idioma:
En
Revista:
Anesthesiology
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão