[Immunodeficiencies and pathologies associated with mutations in STIM/ORAI, a membrane complex in the heart of calcium signalling]. / Immunodéficiences et pathologies associées aux mutations dans STIM/ORAI - Un complexe membranaire au cÅur de la signalisation calcique.
Med Sci (Paris)
; 27(8-9): 737-45, 2011.
Article
em Fr
| MEDLINE
| ID: mdl-21880262
ABSTRACT
Six years ago, STIM1 (stromal interaction molecule 1) was identified as an essential component of store-operated calcium channels and in less than one year teamed up with its first partner ORAI1 in immune cells to reconstitute CRAC (calcium-release activated current) channel function. Since then, STIM1 and ORAI1 have developed an ever increasing social network and to date are now linked to nine families of proteins involved in calcium signalling. As a result of this, STIM1 and ORAI1 are now involved in three separate calcium entry pathways, Icrac, Iarc (arachidonic regulated calcium current) and voltage-dependent channels. Physiopathological roles of STIM1 and ORAI1 were first described in the immunological system but, as main actors at the central node in the calcium signalling network, there are now clear evidences that mutations in genes coding STIM1 or ORAI1 interfere with several other diseases.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Canais de Cálcio
/
Moléculas de Adesão Celular
/
Sinalização do Cálcio
/
Síndromes de Imunodeficiência
/
Transtornos Linfoproliferativos
/
Proteínas de Membrana
/
Doenças Musculares
/
Proteínas de Neoplasias
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Assunto da revista:
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Canadá