[A neuritogenic compound from Tremella fuciformis].
Zhongguo Zhong Yao Za Zhi
; 36(17): 2358-60, 2011 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-22121803
ABSTRACT
OBJECTIVE:
To search for low-molecular-weight neuritogenic compounds from the traditional Chinese medicine (TCM).METHOD:
An extract library of TCM was prepared. Targeted isolation guided by biological screening led to the discovery of compound 1, and its structure was elucidated by analysis of spectroscopic methods and comparison of spectroscopic data with these reported from the literature.RESULT:
A neuritogenic compound 1, 3-O-beta-D-glucopyranosyl-22E, 24R-5alpha, 8alpha-epidioxyergosta-6, 22-diene, was isolated and identified from the methanol extract of T. fuciformis. This compound showed a significant neuritogenic activity against PC12 cells at 3 micromol x L(-1)).CONCLUSION:
Methonal extract of T. fuciformis and targeted compound 1 both showed significant neuritogenic activity against PC12 cells. These results suggested that the extract and compound 1 might be used to prevent and treat neurodegenerative disease such as Alzheimer's disease.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Basidiomycota
/
Medicamentos de Ervas Chinesas
/
Fator de Crescimento Neural
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China