Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers.
Clin Ther
; 34(3): 654-67, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22381714
ABSTRACT
BACKGROUND:
γ-Secretase inhibitors (GSIs) are being investigated for their potential to modify the progression of Alzheimer disease based on their ability to regulate amyloid-ß (Aß) accumulation. BMS-708163 (avagacestat) is an oral GSI designed for selective inhibition of Aß synthesis currently in development for the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aß synthesis, GSIs affect Notch processing, which is thought to mediate some toxic adverse effects reported with this drug class. Avagacestat produced up to 190-fold greater selectivity for Aß synthesis than Notch processing in preclinical studies and may therefore produce less toxic adverse events than other less selective compounds. Presented here are the results of the first in-human study for this new GSI compound.OBJECTIVE:
The goal of this study was to assess the tolerability profile, pharmacokinetic properties, and effects on pharmacodynamic markers (Aß, trefoil factor family 3 protein, dual specificity phosphatase 6, and hairy and enhancer of split-1) of single, oral doses of avagacestat in healthy, young, male volunteers.METHODS:
This was a multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study in 8 healthy young men (age, 18-45 years) per dosing panel. Each study participant was randomized to receive a single dose of placebo (n = 2) or avagacestat (n = 6 for each dose) as an oral solution in 1 of 9 sequential dose panels (0.3, 1.5, 5, 15, 50, 100, 200, 400, and 800 mg). For determination of avagacestat, blood samples were obtained before dosing and for up to 144 hours after dosing. For participants in the 800-mg avagacestat dose panel, additional samples were obtained at 216, 312, and 648 hours. For 40-amino acid isoform of Aß (Aß(1-40)) assessment, plasma samples were collected before avagacestat administration and up to 72 hours after dosing.RESULTS:
Avagacestat concentrations peaked quickly after oral administration and then had a biphasic decrease in concentrations with a prolonged terminal phase. Exposures were proportional with doses up to 200 mg. Avagacestat was well tolerated at single oral doses up to 800 mg, with a biphasic effect on plasma Aß(1-40). Adverse events were predominately mild to moderate in severity with no evidence of dose dependence up to 200 mg.CONCLUSIONS:
Results from this single-ascending dose study suggest that avagacestat was tolerated at a single-dose range of 0.3 to 800 mg and suitable for further clinical development.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
/
Sulfonamidas
/
Biomarcadores
/
Secretases da Proteína Precursora do Amiloide
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Humans
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Male
Idioma:
En
Revista:
Clin Ther
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos