Growth hormone secretagogue receptor antagonists.
Expert Opin Ther Pat
; 22(6): 697-700, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22537050
ABSTRACT
The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists. One of these peptides, among the few that have been studied in vivo, was shown to be able to reduce food intake and body weight gain in rats.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Desenho de Fármacos
/
Fármacos Antiobesidade
/
Receptores de Grelina
/
Antagonistas de Hormônios
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Expert Opin Ther Pat
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália