Association of variants in estrogen-related pathway genes with prostate cancer risk.
Prostate
; 73(1): 1-10, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-22549291
ABSTRACT
BACKGROUND:
Through mediation of estrogen receptors, estradiol has been shown to have both carcinogenic and anti-carcinogenic effects on the prostate. We performed a population-based case-control study to investigate variants in estrogen-related genes ESR1, ESR2, CYP19A1, CYP1A1, and CYP1B1 and the potential association with risk of prostate cancer (PCa). MATERIALS ANDMETHODS:
We evaluated PCa risk conferred by 73 single nucleotide polymorphisms in 1,304 incident PCa cases and 1,266 age-matched controls. Analysis included stratification by clinical features and assessment of environmental modifiers.RESULTS:
There was evidence of altered risk of developing PCa for variants in ESR1, CYP1A1, and CYP1B1, however, only CYP1B1 rs1056836 retained significance after adjustment for multiple comparisons. An association with risk for more aggressive PCa was observed for variants in ESR1, ESR2, and CYP19A1, but none was significant after adjustment for multiple comparisons. There was no effect modification by obesity.CONCLUSIONS:
Germline genetic variation of these estrogen pathway genes may contribute to risk of PCa. Additional studies to validate these results and examine the functional consequence of validated variants are warranted.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Prostata
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Hidrocarboneto de Aril Hidroxilases
/
Citocromo P-450 CYP1A1
/
Polimorfismo de Nucleotídeo Único
/
Receptor alfa de Estrogênio
/
Receptor beta de Estrogênio
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Prostate
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos