Mini-review: the evolution of neuropeptide signaling.
Regul Pept
; 177 Suppl: S6-9, 2012 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-22726357
ABSTRACT
Neuropeptides and their G protein-coupled receptors (GPCRs) have an early evolutionary origin and are already abundant in basal animals with primitive nervous systems such as cnidarians (Hydra, jellyfishes, corals, and sea anemones). Most animals emerging after the Cnidaria belong to two evolutionary lineages, the Protostomia (to which the majority of invertebrates belong) and Deuterostomia (to which some minor groups of invertebrates, and all vertebrates belong). These two lineages split about 700 million years (Myr) ago. Many mammalian neuropeptide GPCRs have orthologues in the Protostomia and this is also true for some of the mammalian neuropeptides. Examples are oxytocin/vasopressin, GnRH, gastrin/CCK, and neuropeptide Y and their GPCRs. These results implicate that protostomes (for example insects and nematodes) can be used as models to study the biology of neuropeptide signaling.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
Transdução de Sinais
/
Evolução Molecular
Limite:
Animals
Idioma:
En
Revista:
Regul Pept
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Dinamarca