Prediction of the shrinking rate of uterine leiomyoma nodules using needle biopsy specimens.
Fertil Steril
; 98(2): 440-3, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22749217
ABSTRACT
OBJECTIVE:
To determine correlations between shrinkage of uterine leiomyomas after treatment with GnRH agonists (GnRH-a) or menopause and expression levels of estrogen receptors (ER), progesterone receptors (PR), and vascular endothelial growth factor (VEGF).DESIGN:
Cohort study.SETTING:
University teaching hospital. PATIENT(S) A total of 26 women with uterine leiomyoma. INTERVENTION(S) Ten women were treated with buserelin acetate injection (1.8 mg), four courses every 4 weeks, and 16 women went into menopause naturally. MAIN OUTCOME MEASURE(S) Tumor shrinkage rates determined from magnetic resonance images taken before and after GnRH-a therapy and before and after natural menopause; immunohistochemical analysis of ER, PR, and VEGF in uterine leiomyoma biopsy specimens taken before intervention or within 6 months before menopause. RESULT(S) Shrinkage rates of uterine leiomyomas were positively correlated with expression levels of ER in women treated with GnRH-a and in postmenopausal women managed conservatively, and with VEGF expression in women treated with GnRH-a. There were no significant correlations with PR expression levels in either group. CONCLUSION(S) Estrogen plays the predominant role in myoma shrinkage for women with GnRH-a therapy and naturally menopausal women.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Saude_da_mulher
/
Colo_do_utero
/
Tipos_de_cancer
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Colo_do_utero
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Uterinas
/
Leiomioma
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão