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Inhibitory effects of baicalin on orthotopic xenografts of colorectal cancer cells that are deficient in a mismatch repair gene in nude mice.
Yang, Bo-Lin; Chen, Hong-Jin; Chen, Yu-Gen; Gu, Yun-Fei; Zhang, Shu-Peng; Lin, Qiu; Sun, Yu.
Afiliação
  • Yang BL; Nanjing University of Traditional Chinese Medicine Hospital, 210029, Nanjing, China. blyang1971@163.com
Int J Colorectal Dis ; 28(4): 547-53, 2013 Apr.
Article em En | MEDLINE | ID: mdl-22914965
OBJECTIVE: The aim of this article is to study the inhibitory effects of baicalin on the growth and metastasis of orthotopic xenografts consisting of human HCT-116 colorectal cancer cells that are deficient in the mismatch repair gene hMLH1 in nude mice. METHODS: A fluorescent orthotopic transplantation model of HCT-116 cells was established. The treatment groups were administered baicalin 50 mg/kg (G2), 100 mg/kg (G3), and 200 mg/kg (G4), and the negative control group (G1) was administered 5 % NaHCO3. The volume and vascular density of the primary tumors, body weights, survival conditions, and death rates of the mice were analyzed. RESULTS: On the 14th, 21st, and 28th days, tumor volume in the treatment groups was significantly smaller than that in the control group, and the differences were statistically significant. At the end of the experiment, the survival rate of the experimental animals in the G3 was significantly higher than that in the G1 and G4 (P < 0.05). There were no significant differences in both the weights and surface vascular densities of the primary tumor and the metastatic tumor among all groups. CONCLUSION: Baicalin had a significant inhibitory effect on the growth of nude mouse orthotopic xenografts consisting of human HCT-116 colorectal tumor cells that are deficient in the mismatch repair gene hMLH1.
Assuntos

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Assunto principal: Flavonoides / Proteínas Nucleares / Neoplasias Colorretais / Ensaios Antitumorais Modelo de Xenoenxerto / Proteínas Adaptadoras de Transdução de Sinal / Reparo de Erro de Pareamento de DNA Limite: Animals / Humans Idioma: En Revista: Int J Colorectal Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Assunto principal: Flavonoides / Proteínas Nucleares / Neoplasias Colorretais / Ensaios Antitumorais Modelo de Xenoenxerto / Proteínas Adaptadoras de Transdução de Sinal / Reparo de Erro de Pareamento de DNA Limite: Animals / Humans Idioma: En Revista: Int J Colorectal Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China