Design of deformable chitosan microspheres loaded with superparamagnetic iron oxide nanoparticles for embolotherapy detectable by magnetic resonance imaging.
Carbohydr Polym
; 90(4): 1725-31, 2012 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-22944439
ABSTRACT
The purpose of this study was to design chitosan microspheres (MS) loaded with superparamagnetic iron oxide nanoparticles (SPIO) suitable for anti-cancer embolotherapy detectable by MRI. Deformable chitosan MS loaded with varying SPIO concentrations (SPIO-chitosan MS) were prepared by ionotropic gelation and a porogenic technique using polyethylene glycol, followed by genipin crosslinking. Adding SPIO nanoparticles to chitosan MS did not significantly affect the chitosan MS morphology. An in vitro phantom study led to selecting SPIO-chitosan MS prepared with 1.0 mM SPIO for an in vivo MR traceability study. SPIO-chitosan MS could be identified following embolization in the renal artery by MRI at 18 weeks. Histological and pathological evidence also showed that SPIO-chitosan MS blocked and remained in the target vessels. Therefore, deformable SPIO-chitosan MS is MR-detectable embolic material with a possible application for anti-cancer embolotherapy.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Prevencao_e_fatores_de_risco
/
Agentes_cancerigenos
Base de dados:
MEDLINE
Assunto principal:
Obstrução da Artéria Renal
/
Compostos Férricos
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Quitosana
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Embolização Terapêutica
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Nanopartículas Metálicas
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Microesferas
Limite:
Animals
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Coréia do Sul