Combined analysis of genome-wide expression and copy number profiles to identify key altered genomic regions in cancer.
BMC Genomics
; 13 Suppl 5: S5, 2012.
Article
em En
| MEDLINE
| ID: mdl-23095915
ABSTRACT
BACKGROUND:
Analysis of DNA copy number alterations and gene expression changes in human samples have been used to find potential target genes in complex diseases. Recent studies have combined these two types of data using different strategies, but focusing on finding gene-based relationships. However, it has been proposed that these data can be used to identify key genomic regions, which may enclose causal genes under the assumption that disease-associated gene expression changes are caused by genomic alterations.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Genoma Humano
/
Glioblastoma
/
Dosagem de Genes
/
Genômica
/
Transcriptoma
/
Modelos Genéticos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
BMC Genomics
Assunto da revista:
GENETICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha