Neutralization activity and kinetics of two broad-range human monoclonal IgG1 derived from recombinant Fab fragments and directed against Hepatitis C virus E2 glycoprotein.
New Microbiol
; 35(4): 475-9, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23109015
ABSTRACT
Hepatitis C virus (HCV) is the major cause of chronic liver disease worldwide. There is evidence that neutralizing anti-HCV antibodies may find potential applications in novel prophylactic and therapeutic strategies. This paper describes the very high neutralization activity and unique biological features of two broadly cross-reactive and cross-neutralizing anti-HCV human monoclonal IgG1 derived from human monoclonal recombinant Fab fragments.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Fragmentos Fab das Imunoglobulinas
/
Proteínas do Envelope Viral
/
Hepatite C
/
Hepacivirus
/
Anticorpos Anti-Hepatite C
/
Anticorpos Monoclonais
Limite:
Humans
Idioma:
En
Revista:
New Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália