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Correlation between therapy response assessment using FDG PET/CT and histopathologic tumor regression grade in hepatic metastasis of colorectal carcinoma after neoadjuvant therapy.
Burger, Irene A; Schwarz, Esther I; Samarin, Andrei; Breitenstein, Stefan; Weber, Achim; Hany, Thomas F.
Afiliação
  • Burger IA; Division of Nuclear Medicine, Department Medical Radiology, University Hospital Zurich, Ramistr. 100, 8091, Zurich, Switzerland. irene.burger@usz.ch
Ann Nucl Med ; 27(2): 177-83, 2013 Feb.
Article em En | MEDLINE | ID: mdl-23233085
ABSTRACT

PURPOSE:

To evaluate the correlation between change in FDG uptake before and after chemotherapy in hepatic metastases of colorectal carcinoma (HCRC) and a histopathologic tumor regression grade (TRG).

METHODS:

In patients with HCRC, PET/CT data prior to hepatic surgery were retrospectively analyzed under an IRB waiver. The maximum standard uptake value (SUVmax) was measured before and after chemotherapy. The relative change of FDG activity in the identified lesions was calculated (dSUV). Histopathological specimens of resected metastases were graded on a 5-score TRG scale. A TRG of 1-3 was rated as a responding to therapy, whereas TRG 4-5 were regarded as non-responding lesions.

RESULTS:

31 lesions were identified in 23 patients. Mean SUVmax before and after therapy was 6.9 ± 3.7 and 3.5 ± 1.8, respectively. The area under the receiver operator characteristic curve revealed a conclusive correlation between TRG and dSUV (AUC 0.773; 95% confidence interval 0.599-0.946) with a cut off at 41% decrease in FDG activity yielding a sensitivity and specificity of 72 and 75%, respectively.

CONCLUSION:

A relative change in FDG activity (dSUV) of more than 41% decrease correlated significantly with histopathological tumor regression and might be a prognostic tool for response to chemotherapy in HCRC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Tomografia Computadorizada por Raios X / Fluordesoxiglucose F18 / Terapia Neoadjuvante / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Ann Nucl Med Assunto da revista: MEDICINA NUCLEAR Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Suíça

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Tomografia Computadorizada por Raios X / Fluordesoxiglucose F18 / Terapia Neoadjuvante / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Ann Nucl Med Assunto da revista: MEDICINA NUCLEAR Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Suíça