Iron deficiency anemia and levels of oxidative stress induced by treatment modality.
Pediatr Int
; 55(3): 289-95, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23316876
ABSTRACT
BACKGROUND:
The effects of iron deficiency anemia (IDA) and its treatment on plasma total antioxidant capacity (TAOC) were investigated.METHODS:
Sixty patients with IDA and 20 healthy controls were divided into four subgroups an oral (per os PO) group (n = 20); an intramuscular (IM) group (n = 20); an intravenous (IV) group (n = 20); and the control group (n = 20). Blood samples were obtained from all patients before treatment, and at 24 h, 7 days, 6 and 13 weeks after initiation of IDA therapy.RESULTS:
TAOC in the IDA group was low when compared with the control group (P < 0.001). Although TAOC at 24 h in the PO group was not different from the control group, the TAOC in the IM and IV groups was relatively lower (P < 0.001). The TAOC in the PO group at 7 days, and at 6 and 13 weeks was closest to the control group level. The mean TAOC in the IV group at 13 weeks was clearly lower relative to the PO and IM groups.CONCLUSIONS:
Oxidative stress was minimally induced with oral therapy, while IM and IV therapies induced higher levels of oxidative stress, in increasing order of intensity.
Texto completo:
1
Coleções:
01-internacional
Temas:
Agentes_cancerigenos
Base de dados:
MEDLINE
Assunto principal:
Sacarose
/
Compostos Férricos
/
Compostos Ferrosos
/
Estresse Oxidativo
/
Anemia Ferropriva
/
Países em Desenvolvimento
/
Glicina
/
Antioxidantes
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Pediatr Int
Assunto da revista:
PEDIATRIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Turquia