Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.
Mol Cell Biol
; 33(14): 2797-808, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23689134
ABSTRACT
The involvement of nuclear factor kappa B (NF-κB) in several processes in the postnatal and adult brain, ranging from neuronal survival to synaptogenesis and plasticity, has been documented. In contrast, little is known about the functions of NF-κB during embryonic brain development. It is shown here that NF-κB is selectively activated in neocortical neural progenitor cells in the developing mouse telencephalon. Blockade of NF-κB activity leads to premature cortical neuronal differentiation and depletion of the progenitor cell pool. Conversely, NF-κB activation causes decreased cortical neurogenesis and expansion of the progenitor cell compartment. These effects are antagonized by the proneuronal transcription factor Hes6, which physically and functionally interacts with RelA-containing NF-κB complexes in cortical progenitor cells. In turn, NF-κB exerts an inhibitory effect on the ability of Hes6 to promote cortical neuronal differentiation. These results reveal previously uncharacterized functions and modes of regulation for NF-κB and Hes6 during cortical neurogenesis.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Neocórtex
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Fatores de Transcrição Hélice-Alça-Hélice Básicos
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Subunidade p50 de NF-kappa B
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Fator de Transcrição RelA
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Neurogênese
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Mol Cell Biol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Canadá