Sinus histiocytosis with massive lymphadenopathy: immunological, cytogenetic and molecular studies.
Blut
; 60(6): 339-44, 1990 Jun.
Article
em En
| MEDLINE
| ID: mdl-2375964
ABSTRACT
We describe a case of "sinus histiocytosis with massive lymphadenopathy" (SHML) studied by immunohistochemical, cytogenetic and molecular analysis. The immunophenotyping showed that the lymph node histiocytes were strongly positive for the S-100 protein and MoAb LeuM3, OKM5, KP1 and DRC-1; a portion of these cells was also positive for OKT6 and Leu3A, suggesting a possible relationship with the veiled cells, which represent an intermediate step in the pathway from the Langerhans cell to the interdigitating reticulum cell. Cytogenetic analysis showed a normal prevalent clone and a small hypodiploid clone and the molecular study showed no detectable involvement of the c-fms proto-oncogene, which is related to monocyte/macrophages. Unfortunately all these data do not seem sufficient to define the benign or neoplastic nature of the disease. Further investigations, immunophenotypical, cytogenetic and molecular, are needed to elucidate the pathogenesis of the disease, especially for more aggressive cases or for cases with unfavorable evolution.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Histiocitose Sinusal
/
Doenças Linfáticas
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Blut
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Itália