The activities of acid DNase and 5'nucleotidase in erosive reflux esophagitis and Barrett's epithelium.
Hepatogastroenterology
; 60(125): 1073-6, 2013.
Article
em En
| MEDLINE
| ID: mdl-23803371
ABSTRACT
BACKGROUND/AIMS:
The study examines the relationship between activity of acid DNase and 5'nucleotidase (5'NT) and histological changes in reflux esophagitis.METHODOLOGY:
Thirty-three patients were examined, 15 of whom with mild esophagitis, 12 with severe esophagitis and 6 with Barrett's epithelium. Patients were classified into 3 groups, according to Ismail-Beigi histological criteria mild esophagitis group (ME); severe esophagitis group (SE); Barrett's esophagitis group (BE). DNase and 5'NT levels were measured biochemically both in healthy and injured tissue samples.RESULTS:
Difference of acid DNase and 5'NT activity in healthy tissue versus injured tissue samples was the lowest in ME group 0.55±4.47 U/g for acid DNase and 11.56±37.11 U/g for 5'NT, the difference increased to 4.43±1.64 U/g for acid DNase and 105.57±54.11 U/g for 5'NT in the SE group, while 6.07±2.92 U/g for acid DNase and 109.83±14.02 U/g for 5'NT as the highest levels were measured in the BE group. Difference in BE group is statistically significantly higher (p <0.05) compared to the ME group, confirmed by ANOVA with Dunnett's post hoc test.CONCLUSIONS:
The study shows significant decrease of apotosis level that is detectable even before metaplasia was morphologically defined.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Esôfago de Barrett
/
Esofagite Péptica
/
5'-Nucleotidase
/
Desoxirribonucleases
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Hepatogastroenterology
Ano de publicação:
2013
Tipo de documento:
Article