Vascular cell adhesion molecule 1, soluble Fas and hepatocyte growth factor as predictors of mortality in nonagenarians: the Vitality 90+ study.
Exp Gerontol
; 48(11): 1167-72, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23911532
ABSTRACT
BACKGROUND:
Ageing is characteristically accompanied by changes in vascular endothelial markers and growth factor as well as increased cellular death. We analysed the associations of the plasma levels of vascular cell adhesion molecule-1 (VCAM-1), hepatocyte growth factor (HGF) and soluble Fas (sFAS), and their combinations, with 4-year mortality to identify new biomarkers.METHODS:
A total of 238 individuals, both community-dwelling and institutionalised, aged 89 91 years and participating in the Vitality 90+ study were included. Biomarkers of endothelial function (VCAM-1), growth factor (HGF) and a marker of apoptosis (sFAS) were determined from plasma using Luminex® technology. This newly-determined data was combined with earlier data, e.g., 4-year mortality and medical history.RESULTS:
Subjects who died during the follow-up had higher baseline plasma levels of VCAM-1, sFas, and HGF. When other known risk factors were adjusted for, subjects in the highest concentration tertile for VCAM-1 (HR 1.85; 95% CI, 1.12-3.05) and HGF (HR 2.22; 95% CI, 1.33-3.71) had higher mortality compared to those in the lowest tertile. In the adjusted analyses, when compared to subjects with none of the biomarkers in the highest concentration tertile, mortality was also higher when sFas and VCAM-1 were simultaneously (HR 2.03; 95% CI, 1.13-3.64) or all three were simultaneously (HR 3.63; 95% CI, 1.65-7.97) in the highest concentration tertile.CONCLUSIONS:
Our results suggest that increased concentrations of these biomarkers, separately and in combination, associate with mortality among the aged and are prognostic markers of death.Palavras-chave
(BMI); (CRP); (HGF); (IL-1Ra); (TNF-α); (VCAM-1); (hs-CRP); (sFas); C-reactive protein; Hepatocyte growth factor; Mortality; Nonagenarians; Soluble Fas; Vascular cell adhesion molecule 1; body mass index; hepatocyte growth factor; high-sensitivity C-reactive protein; interleukin 1 receptor antagonist; soluble Fas; tumour necrosis factor-alpha; vascular cell adhesion molecule 1
Texto completo:
1
Coleções:
01-internacional
Temas:
Mortalidade
/
Geral
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Fator de Crescimento de Hepatócito
/
Molécula 1 de Adesão de Célula Vascular
/
Receptor fas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Exp Gerontol
Ano de publicação:
2013
Tipo de documento:
Article