No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
Hum Genet
; 132(12): 1427-31, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24100633
ABSTRACT
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Etnicidade
/
Fumar
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Polimorfismo de Nucleotídeo Único
/
Metabolismo dos Lipídeos
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Estudo de Associação Genômica Ampla
/
Interação Gene-Ambiente
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Hum Genet
Ano de publicação:
2013
Tipo de documento:
Article