The effects of levetiracetam on neural tube development in the early stage of chick embryos.
Turk Neurosurg
; 23(5): 617-22, 2013.
Article
em En
| MEDLINE
| ID: mdl-24101309
ABSTRACT
AIM:
This study aimed to investigate the effects of a new generation antiepileptic agent, levetiracetam, on the neural tube development in a chick embryo model that corresponds to the first month of vertebral development in mammals. MATERIAL ANDMETHODS:
Forty-five Atabey® breed fertilized chicken eggs with no specific pathogens were randomly divided into 5 groups. All of the eggs were incubated at 37.8±2°C and 60±5 % relative humidity in an incubator. Group A was control group. The other eggs were applied physiological saline and drugs at a volume of 10 µL by the in ovo method at the 28th hour of the incubation period. Group B was given distilled water; Group C, physiological saline; Group D, Levetiracetam (L8668) at a dose equivalent to the treatment dose for humans (10 mg/ kg), and Group E, Levetiracetam (L8668) at a dose of 10 times the treatment dose. The embryos in all of the groups were removed from the shells at the 48th hour and morphologically and histologically evaluated.RESULTS:
Of the 45 embryos incubated, neural tubes of 41 were closed and the embryos displayed normal development.CONCLUSION:
Levetiracetam, at a dose equivalent to human treatment dose and 10 times the treatment dose, was shown not to cause neural tube defects in chick embryos.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Piracetam
/
Tubo Neural
/
Anticonvulsivantes
/
Defeitos do Tubo Neural
Limite:
Animals
Idioma:
En
Revista:
Turk Neurosurg
Assunto da revista:
NEUROCIRURGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Turquia