Regulation of activity of transcription factor NF-κB by synthetic oligonucleotides.
Biochemistry (Mosc)
; 78(8): 867-78, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-24228874
ABSTRACT
Eukaryotic dimeric nuclear factor-κB (NF-κB) is one of the main transcription factors that activate expression of genes, products of which play the key role in development of cardiovascular pathologies, carcinogenesis, and inflammatory and viral diseases. In this review, the main attention is given to modulation of the transcription factor NF-κB activity by antisense oligonucleotides and oligonucleotide decoys. Also, current concepts about interactions between NF-κB dimers and DNA and general problems that arise in experimental use of synthetic oligonucleotides in vivo are discussed.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
NF-kappa B
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Federação Russa