Your browser doesn't support javascript.
loading
Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes.
Wu, Jian; Ding, Yaqing; Zhu, Chunling; Shao, Xiaohong; Xie, Xin; Lu, Kan; Wang, Rui.
Afiliação
  • Wu J; Department of Endocrinology, Shanghai TCM-Integrated Hospital, Shanghai 200082, P.R. China.
Exp Ther Med ; 6(6): 1482-1488, 2013 Dec.
Article em En | MEDLINE | ID: mdl-24250725
ABSTRACT
The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-α and NGAL were measured in 63 non-diabetic controls and 201 patients with type 2 diabetes and different albuminuria statuses. The patients with diabetes (n=125) with normo- or microalbuminuria were subsequently followed-up for 28 (25-32) months, with routine measurements of creatinine and urinary albumin excretion (UAE). It was observed that baseline levels of urinary TNF-α and NGAL were significantly elevated and correlated with the severity of albuminuria in patients with diabetes. During the follow-up, the urinary levels of TNF-α and NGAL were observed to be significantly correlated with a rapid decline in the estimated glomerular filtration rate (eGFR). Following adjustment for other progression promoters, including albuminuria, TNF-α remained a significant predictor of eGFR decline. These results suggest that inflammation is important in the pathogenesis of DN and indicate that TNF-α may be used as an independent predictor for the progression of DN at the early stage.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Exp Ther Med Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Exp Ther Med Ano de publicação: 2013 Tipo de documento: Article