miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia.
Leuk Res
; 38(3): 402-10, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24484870
ABSTRACT
microRNA profiling of acute myeloid leukemia patient samples identified miR-125a as being decreased. Current literature has investigated miR-125a's role in normal hematopoiesis but not within acute myeloid leukemia. Analysis of the upstream region of miR-125a identified several CpG islands. Both precursor and mature miR-125a increased in response to a de-methylating agent, Decitabine. Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a. Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Leucemia
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
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Regulação Leucêmica da Expressão Gênica
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Proteínas Oncogênicas v-erbB
/
MicroRNAs
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos