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Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood.
Liu, Lu; Detering, Jan-Christoph; Milde, Till; Haefeli, Walter Emil; Witt, Olaf; Burhenne, Jürgen.
Afiliação
  • Liu L; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.
  • Detering JC; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.
  • Milde T; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
  • Haefeli WE; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.
  • Witt O; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
  • Burhenne J; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany. Electronic address: juergen.burhenne@med.uni-heidelberg.de.
J Chromatogr B Analyt Technol Biomed Life Sci ; 964: 212-21, 2014 Aug 01.
Article em En | MEDLINE | ID: mdl-24636840
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Alemanha
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Alemanha