IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
Biochem Biophys Res Commun
; 449(4): 477-82, 2014 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-24845382
ABSTRACT
Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to be able to increase the survival and regeneration of retinal ganglion cells (RGC) in mixed culture as well as in vivo. In this work we show that the trophic effect of IL-6 is mediated by adenosine receptor (A2aR) activation and also by the presence of extracellular BDNF. We also show that there is a complex cross-talk between IL-6, BDNF, the Adenosine A1 and A2a receptors that results in neuroprotection of retinal ganglion cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Células Ganglionares da Retina
/
Interleucina-6
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Fator Neurotrófico Derivado do Encéfalo
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Receptor A1 de Adenosina
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Receptor A2A de Adenosina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2014
Tipo de documento:
Article