Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis.
Gut Microbes
; 5(3): 313-25, 2014.
Article
em En
| MEDLINE
| ID: mdl-24971581
ABSTRACT
The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed a rat model mimicking the natural transmission of E. coli from mothers to neonates. Genotoxic and non-genotoxic E. coli strains were equally transmitted to the offspring and stably colonized the gut across generations. DNA damage was only detected in neonates colonized with genotoxic E. coli strains. Signs of genotoxic stress such as anaphase bridges, higher occurrence of crypt fission and accelerated renewal of the mature epithelium were detected at adulthood. In addition, we observed alterations of secretory cell populations and gut epithelial barrier. Our findings illustrate how critical is the genotype of E. coli strains acquired at birth for gut homeostasis at adulthood.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Dano ao DNA
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Trato Gastrointestinal
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Escherichia coli
/
Policetídeos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
Gut Microbes
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
França