Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds.
Food Chem
; 165: 191-7, 2014 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-25038666
ABSTRACT
[6]-Gingerol and [6]-shogaol are the major pungent components in ginger with a variety of biological activities including antioxidant activity. To explore their structure determinants for antioxidant activity, we synthesized eight compounds differentiated by their side chains which are characteristic of the C1-C2 double bond, the C4-C5 double bond or the 5-OH, and the six- or twelve-carbon unbranched alkyl chain. Our results show that their antioxidant activity depends significantly on the side chain structure, the reaction mediums and substrates. Noticeably, existence of the 5-OH decreases their formal hydrogen-transfer and electron-donating abilities, but increases their DNA damage- and lipid peroxidation-protecting abilities. Additionally, despite significantly reducing their DNA strand breakage-inhibiting activity, extension of the chain length from six to twelve carbons enhances their anti-haemolysis activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Alimentacao
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Catecóis
/
Álcoois Graxos
/
Antioxidantes
Idioma:
En
Revista:
Food Chem
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China