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JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
Degryse, Sandrine; de Bock, Charles E; Cox, Luk; Demeyer, Sofie; Gielen, Olga; Mentens, Nicole; Jacobs, Kris; Geerdens, Ellen; Gianfelici, Valentina; Hulselmans, Gert; Fiers, Mark; Aerts, Stein; Meijerink, Jules P; Tousseyn, Thomas; Cools, Jan.
Afiliação
  • Degryse S; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • de Bock CE; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Cox L; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Demeyer S; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Gielen O; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Mentens N; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Jacobs K; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Geerdens E; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Gianfelici V; Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy;
  • Hulselmans G; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Fiers M; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Aerts S; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
  • Meijerink JP; Department of Pediatric Oncology/Hematology, Erasmus University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, The Netherlands; and.
  • Tousseyn T; Department of Pathology, Universitaire Ziekenhuizen, Leuven, Belgium.
  • Cools J; Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium; Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;
Blood ; 124(20): 3092-100, 2014 Nov 13.
Article em En | MEDLINE | ID: mdl-25193870
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Leucemia / Tratamento Base de dados: MEDLINE Assunto principal: Leucemia de Células T / Transformação Celular Neoplásica / Modelos Animais de Doenças / Janus Quinase 1 / Janus Quinase 3 / Camundongos Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Leucemia / Tratamento Base de dados: MEDLINE Assunto principal: Leucemia de Células T / Transformação Celular Neoplásica / Modelos Animais de Doenças / Janus Quinase 1 / Janus Quinase 3 / Camundongos Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2014 Tipo de documento: Article