Comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells.
J Oleo Sci
; 63(10): 979-85, 2014.
Article
em En
| MEDLINE
| ID: mdl-25213447
ABSTRACT
The effects on lipid metabolism of four different n-3 highly unsaturated fatty acids (n-3HUFA) including eicosapentaenoic acid (EPA, 205n-3), docosapentaenoic acid (DPA, 225n-3), docosahexaenoic acid (DHA, 226n-3), and tetracosahexaenoic acid (THA, 246n-3) were compared in the HepG2 cell model. None of the n-3HUFAs affected the viability of the cells. THA exerted the strongest suppression on the synthesis of triacylglycerol and cholesteryl ester (ChE), and the order of the strength of suppression was found to be THA > DHA > DPA > EPA. The mRNA level of fatty acid synthase was suppressed by the n-3HUFAs and the order of the strength of suppression by n-3HUFAs was the same in both triacylglycerol and ChE synthesis. These findings support previous animal test results using EPA, DPA, and DHA. In conclusion, both the number of carbon atoms and double bonds in an n-3HUFA structure has an effect on lipid metabolism in HepG2 cells.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
/
Metabolismo dos Lipídeos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Oleo Sci
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2014
Tipo de documento:
Article