Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities.
Arch Pharm Res
; 38(5): 604-13, 2015.
Article
em En
| MEDLINE
| ID: mdl-25219454
ABSTRACT
Three novel alkaloids (1-3), together with nineteen known ones (4-22), were isolated from the bulbs of Lycoris longituba. Their structures were elucidated on the basis of extensive spectroscopic analyses, which belong to several Amaryllidaceae alkaloid skeletons. Among them, the harmane-type alkaloids (the new compound 1 and the known compounds 5, 6 and 7) were found for the first time from Lycoris genus. The isolates were tested for their neuroprotective activities against CoCl2, H2O2 and Aß25-35-induced SH-SY5Y cell injuries, and the majority of them exhibited neuroprotective activities of different degrees. The acetylcholinesterase (AChE) inhibitory activities of the isolated alkaloids were also evaluated, while compounds 12, 14-20 and 22 exhibited extremely significant AChE inhibitory activities.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Inibidores da Colinesterase
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Raízes de Plantas
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Fármacos Neuroprotetores
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Lycoris
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Alcaloides
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2015
Tipo de documento:
Article