Evaluation of toxic endpoints for a set of cosmetic ingredients with CAESAR models.
Chemosphere
; 120: 492-9, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25278177
ABSTRACT
The randomly selected set of 558 chemicals from Cosmetic inventory was studied with internet accessible program package CAESAR. Four toxic endpoints were considered mutagenicity, carcinogenicity, developmental toxicity and skin sensitization. The CAESAR program provides beside the predictions comprehensive information on applicability domain and the similarity between the considered compound and the compounds from model's training set. This information was used to implement for clustering and classification of chemicals. As the technique the Self Organizing Maps was applied. This technique also enables us to define to each cluster the cluster indicator, i.e., the characteristic compound, which is considered as a representative for a cluster.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Cosméticos
/
Modelos Teóricos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Chemosphere
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Eslovênia