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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.
Guan, Jian; Mishra, Shikha; Qiu, Yiling; Shi, Jianru; Trudeau, Kyle; Las, Guy; Liesa, Marc; Shirihai, Orian S; Connors, Lawreen H; Seldin, David C; Falk, Rodney H; MacRae, Calum A; Liao, Ronglih.
Afiliação
  • Guan J; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Mishra S; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Qiu Y; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Shi J; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Trudeau K; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Las G; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Liesa M; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Shirihai OS; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Connors LH; Amyloidosis Center, Boston University School of Medicine, Boston, MA, USA.
  • Seldin DC; Amyloidosis Center, Boston University School of Medicine, Boston, MA, USA.
  • Falk RH; Cardiac Amyloidosis Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • MacRae CA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Liao R; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Cardiac Amyloidosis Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA rliao@rics.bwh.harvard.edu.
EMBO Mol Med ; 6(11): 1493-507, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25319546
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Autofagia / Cardiotoxicidade / Amiloidose / Lisossomos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: EMBO Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Autofagia / Cardiotoxicidade / Amiloidose / Lisossomos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: EMBO Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos