Anti-inflammatory effect of methylpenicinoline from a marine isolate of Penicillium sp. (SF-5995): inhibition of NF-&#954;B and MAPK pathways in lipopolysaccharide-induced RAW264.7 macrophages and BV2 microglia.

Kim, Dong-Cheol; Lee, Hee-Suk; Ko, Wonmin; Lee, Dong-Sung; Sohn, Jae Hak; Yim, Joung Han; Kim, Youn-Chul; Oh, Hyuncheol

Anti-inflammatory effect of methylpenicinoline from a marine isolate of Penicillium sp. (SF-5995): inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced RAW264.7 macrophages and BV2 microglia.

Kim, Dong-Cheol; Lee, Hee-Suk; Ko, Wonmin; Lee, Dong-Sung; Sohn, Jae Hak; Yim, Joung Han; Kim, Youn-Chul; Oh, Hyuncheol.

Afiliação

Kim DC; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea. kimman07@hanmail.net.
Lee HS; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea. cutehs22@naver.com.
Ko W; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea. rabis815@naver.com.
Lee DS; Inha Research Institute for Medical Sciences, Inha University School of Medicine, Incheon 400-712, Korea. dongsunglee@inha.ac.kr.
Sohn JH; College of Medical and Life Sciences, Silla University, Busan 617-736, Korea. jhsohn@silla.ac.kr.
Yim JH; Korea Polar Research Institute, KORDI, 7-50 Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea. jhyim@kopri.re.kr.
Kim YC; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea. yckim@wku.ac.kr.
Oh H; Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea. hoh@wku.ac.kr.

Molecules ; 19(11): 18073-89, 2014 Nov 05.

Article em En | MEDLINE | ID: mdl-25379644

Assuntos

Organismos Aquáticos/química; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Macrófagos/metabolismo; Microglia/metabolismo; NF-kappa B/antagonistas & inibidores; Penicillium/química; Animais; Anti-Inflamatórios/química; Anti-Inflamatórios/isolamento & purificação; Anti-Inflamatórios/farmacologia; Linhagem Celular; Ciclo-Oxigenase 2/biossíntese; Dinoprostona/biossíntese; Interleucina-1beta/biossíntese; Lipopolissacarídeos/toxicidade; Macrófagos/patologia; Camundongos; Microglia/patologia; NF-kappa B/metabolismo; Óxido Nítrico Sintase Tipo II/biossíntese

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Penicillium / NF-kappa B / Microglia / Sistema de Sinalização das MAP Quinases / Organismos Aquáticos / Macrófagos Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2014 Tipo de documento: Article

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