Naturally occurring N(6)-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: an in silico evaluation of their interaction with the P2Y(12) receptor.
Bioorg Med Chem Lett
; 24(24): 5652-5655, 2014 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-25467153
ABSTRACT
A few naturally occurring N(6)-substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50 6.77-141 µM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 receptor binding site.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Ribonucleosídeos
/
Plaquetas
/
Inibidores da Agregação Plaquetária
/
Agregação Plaquetária
/
Citocininas
/
Receptores Purinérgicos P2Y12
Tipo de estudo:
Evaluation_studies
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Itália