Receptor-type tyrosine-protein phosphatase &#954; directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma.

Chen, Yun-Wen; Guo, Tianhuan; Shen, Lijun; Wong, Kai-Yau; Tao, Qian; Choi, William W L; Au-Yeung, Rex K H; Chan, Yuen-Piu; Wong, Michelle L Y; Tang, Johnny C O; Liu, Wei-Ping; Li, Gan-Di; Shimizu, Norio; Loong, Florence; Tse, Eric; Kwong, Yok-Lam; Srivastava, Gopesh

Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma.

Chen, Yun-Wen; Guo, Tianhuan; Shen, Lijun; Wong, Kai-Yau; Tao, Qian; Choi, William W L; Au-Yeung, Rex K H; Chan, Yuen-Piu; Wong, Michelle L Y; Tang, Johnny C O; Liu, Wei-Ping; Li, Gan-Di; Shimizu, Norio; Loong, Florence; Tse, Eric; Kwong, Yok-Lam; Srivastava, Gopesh.

Afiliação

Chen YW; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Guo T; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Shen L; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Wong KY; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Tao Q; Cancer Epigenetics Laboratory, Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong;
Choi WW; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Au-Yeung RK; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Chan YP; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Wong ML; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Tang JC; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong;
Liu WP; Department of Pathology, West-China Hospital of Sichuan University, Chengdu, Sichuan, China;
Li GD; Department of Pathology, West-China Hospital of Sichuan University, Chengdu, Sichuan, China;
Shimizu N; Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; and.
Loong F; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;
Tse E; Division of Hematology, Medical Oncology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
Kwong YL; Division of Hematology, Medical Oncology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
Srivastava G; Lymphoma Research Laboratory, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong;

Blood ; 125(10): 1589-600, 2015 Mar 05.

Article em En | MEDLINE | ID: mdl-25612622

Assuntos

Linfoma Extranodal de Células T-NK/metabolismo; Neoplasias Nasais/metabolismo; Proteínas Tirosina Fosfatases Classe 2 Semelhantes a Receptores/metabolismo; Fator de Transcrição STAT3/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Apoptose; Caspases/metabolismo; Linhagem Celular Tumoral; Núcleo Celular/metabolismo; Proliferação de Células; Metilação de DNA; Análise Mutacional de DNA; Regulação para Baixo; Feminino; Deleção de Genes; Técnicas de Silenciamento de Genes; Humanos; Linfoma Extranodal de Células T-NK/genética; Linfoma Extranodal de Células T-NK/patologia; Masculino; Pessoa de Meia-Idade; Invasividade Neoplásica; Neoplasias Nasais/genética; Neoplasias Nasais/patologia; Fosforilação; Prognóstico; Regiões Promotoras Genéticas; Ligação Proteica; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; RNA Neoplásico/genética; RNA Neoplásico/metabolismo; Proteínas Tirosina Fosfatases Classe 2 Semelhantes a Receptores/deficiência; Proteínas Tirosina Fosfatases Classe 2 Semelhantes a Receptores/genética; Fator de Transcrição STAT3/química; Proteínas Supressoras de Tumor/deficiência; Proteínas Supressoras de Tumor/genética

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Nasais / Proteínas Supressoras de Tumor / Fator de Transcrição STAT3 / Linfoma Extranodal de Células T-NK / Proteínas Tirosina Fosfatases Classe 2 Semelhantes a Receptores Tipo de estudo: Prognostic_studies Idioma: En Revista: Blood Ano de publicação: 2015 Tipo de documento: Article

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