The effects of RegM on stress responses in Brucella melitensis.
Curr Microbiol
; 70(5): 730-4, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25648428
ABSTRACT
Brucella melitensis is a facultative intracellular pathogen. The regM gene encodes a sensory transduction protein kinase in B. melitensis 16M, and genes orthologous to regM have been found to exist in many bacterial species. However, little is known about the regulation function of this gene in Brucella. In order to characterize this gene, we constructed a marked deletion mutant of regM as well as its complemented strain. The mutant was less able to withstand acid and hyperosmotic conditions than wild-type strain but shown no significant difference with wild-type strain when challenged by elevated temperature and hypotonic conditions. In addition, inactivation of regM did not affect virulence in B. melitensis 16M in macrophage and mice infection models.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Estresse Fisiológico
/
Regulação Bacteriana da Expressão Gênica
/
Brucella melitensis
Limite:
Animals
Idioma:
En
Revista:
Curr Microbiol
Ano de publicação:
2015
Tipo de documento:
Article