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Differential expression of TOX by skin-infiltrating T cells in Sézary syndrome and erythrodermic dermatitis.
Boonk, Stephanie E; Çetinözman, Fatma; Vermeer, Maarten H; Jansen, Patty M; Willemze, Rein.
Afiliação
  • Boonk SE; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
  • Çetinözman F; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
  • Vermeer MH; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
  • Jansen PM; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
  • Willemze R; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
J Cutan Pathol ; 42(9): 604-9, 2015 Sep.
Article em En | MEDLINE | ID: mdl-25777533
BACKGROUND: The histopathologic differentiation between Sézary syndrome (SS) and erythrodermic dermatitis may be extremely difficult. In this immunohistochemical study, it was investigated if thymocyte selection-associated high mobility group box protein (TOX) and C-MYC can be used as additional diagnostic markers to differentiate between SS and erythrodermic dermatitis. METHOD: Paraffin-embedded skin biopsies from 15 SS patients and 17 erythrodermic dermatitis patients were stained and scored for TOX or C-MYC expression. RESULTS: Strong nuclear staining for TOX in more than 50% of skin-infiltrating T cells was observed in 13 of 15 (87%) SS cases, whereas erythrodermic dermatitis cases showed weak nuclear staining in 11-50% (median: 25%) of the T cells; strong nuclear staining as found in SS was never observed in erythrodermic dermatitis. No significant differences in C-MYC expression between SS and erythrodermic dermatitis were found. In most patients of both groups, percentages of C-MYC positive-cells varied between less than 10 and 25% of skin-infiltrating T cells. CONCLUSION: Our results suggest that strong expression of TOX in more than 50% of skin-infiltrating T cells in erythrodermic skin is a useful marker in the differentiation between SS and erythrodermic dermatitis, whereas staining for C-MYC does not contribute to differential diagnosis.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Proteínas de Grupo de Alta Mobilidade / Linfócitos T / Síndrome de Sézary Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Cutan Pathol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Proteínas de Grupo de Alta Mobilidade / Linfócitos T / Síndrome de Sézary Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Cutan Pathol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda