Platelet-Derived Growth Factor Receptor-&#945; Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.

Hayashi, Yujiro; Bardsley, Michael R; Toyomasu, Yoshitaka; Milosavljevic, Srdjan; Gajdos, Gabriella B; Choi, Kyoung Moo; Reid-Lombardo, K Marie; Kendrick, Michael L; Bingener-Casey, Juliane; Tang, Chih-Min; Sicklick, Jason K; Gibbons, Simon J; Farrugia, Gianrico; Taguchi, Takahiro; Gupta, Anu; Rubin, Brian P; Fletcher, Jonathan A; Ramachandran, Abhijit; Ordog, Tamas

Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.

Hayashi, Yujiro; Bardsley, Michael R; Toyomasu, Yoshitaka; Milosavljevic, Srdjan; Gajdos, Gabriella B; Choi, Kyoung Moo; Reid-Lombardo, K Marie; Kendrick, Michael L; Bingener-Casey, Juliane; Tang, Chih-Min; Sicklick, Jason K; Gibbons, Simon J; Farrugia, Gianrico; Taguchi, Takahiro; Gupta, Anu; Rubin, Brian P; Fletcher, Jonathan A; Ramachandran, Abhijit; Ordog, Tamas.

Afiliação

Hayashi Y; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota.
Bardsley MR; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota.
Toyomasu Y; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota.
Milosavljevic S; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota.
Gajdos GB; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota.
Choi KM; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Reid-Lombardo KM; Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Kendrick ML; Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Bingener-Casey J; Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Tang CM; Division of Surgical Oncology, Moores Cancer Center, University of California, San Diego, California.
Sicklick JK; Division of Surgical Oncology, Moores Cancer Center, University of California, San Diego, California.
Gibbons SJ; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Farrugia G; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.
Taguchi T; Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Kochi, Japan.
Gupta A; Departments of Pathology and Molecular Genetics, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio.
Rubin BP; Departments of Pathology and Molecular Genetics, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio.
Fletcher JA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Ramachandran A; AROG Pharmaceuticals, LLC, Dallas, Texas.
Ordog T; Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: ordog.tamas@mayo.edu.

Gastroenterology ; 149(2): 420-32.e16, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25865047

Assuntos

Proliferação de Células/genética; Proteínas de Ligação a DNA/genética; Tumores do Estroma Gastrointestinal/metabolismo; Proteínas Proto-Oncogênicas c-kit/metabolismo; Receptor alfa de Fator de Crescimento Derivado de Plaquetas/metabolismo; Transdução de Sinais/genética; Fatores de Transcrição/genética; Animais; Benzamidas/metabolismo; Benzimidazóis/metabolismo; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Citometria de Fluxo; Tumores do Estroma Gastrointestinal/genética; Técnicas de Silenciamento de Genes/métodos; Humanos; Mesilato de Imatinib; Imuno-Histoquímica; Camundongos; Camundongos Endogâmicos BALB C; Mutação; Precursores de Ácido Nucleico/genética; Fosforilação/genética; Piperazinas/metabolismo; Piperidinas/metabolismo; Proteínas Proto-Oncogênicas c-kit/genética; Pirimidinas/metabolismo; Receptor alfa de Fator de Crescimento Derivado de Plaquetas/genética; Receptor beta de Fator de Crescimento Derivado de Plaquetas/metabolismo

Palavras-chave

Cancer; Receptor Tyrosine Kinase; Signal Transduction; Stem Cells

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Transdução de Sinais / Proteínas Proto-Oncogênicas c-kit / Receptor alfa de Fator de Crescimento Derivado de Plaquetas / Tumores do Estroma Gastrointestinal / Proliferação de Células / Proteínas de Ligação a DNA Limite: Animals / Humans Idioma: En Revista: Gastroenterology Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google