An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates.

O'Day, Elizabeth; Le, Minh T N; Imai, Shunsuke; Tan, Shen Mynn; Kirchner, Rory; Arthanari, Haribabu; Hofmann, Oliver; Wagner, Gerhard; Lieberman, Judy

O'Day, Elizabeth; Le, Minh T N; Imai, Shunsuke; Tan, Shen Mynn; Kirchner, Rory; Arthanari, Haribabu; Hofmann, Oliver; Wagner, Gerhard; Lieberman, Judy.

Afiliação

O'Day E; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115; Cellular and Molecular Medicine Program, Boston Children's Hospital, Boston, Massachusetts 02115.
Le MTN; Cellular and Molecular Medicine Program, Boston Children's Hospital, Boston, Massachusetts 02115.
Imai S; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
Tan SM; Cellular and Molecular Medicine Program, Boston Children's Hospital, Boston, Massachusetts 02115.
Kirchner R; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115.
Arthanari H; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
Hofmann O; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115.
Wagner G; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115. Electronic address: Gerhard_wagner@hms.harvard.edu.
Lieberman J; Cellular and Molecular Medicine Program, Boston Children's Hospital, Boston, Massachusetts 02115. Electronic address: Judy.Lieberman@childrens.harvard.edu.

J Biol Chem ; 290(29): 17909-17922, 2015 Jul 17.

Article em En | MEDLINE | ID: mdl-26045559

Assuntos

Quadruplex G; MicroRNAs/química; MicroRNAs/metabolismo; Proteínas de Ligação a RNA/metabolismo; Animais; Sequência de Bases; Linhagem Celular; Humanos; Mesoporfirinas/metabolismo; Camundongos; MicroRNAs/genética; Modelos Moleculares; Dados de Sequência Molecular; Mutação; Ligação Proteica; RNA Mensageiro/química; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

Palavras-chave

G-quartet; Lin28; N-methyl mesoporphyrin IX (NMM); cancer; embryonic stem cell; fluorescence; let-7; microRNA (miRNA); nuclear magnetic resonance (NMR)

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a RNA / MicroRNAs / Quadruplex G Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2015 Tipo de documento: Article

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