CD47 deficiency ameliorates autoimmune nephritis in Fas(lpr) mice by suppressing IgG autoantibody production.

Shi, Lei; Bian, Zhen; Chen, Celia X J; Guo, Ya-Nan; Lv, Zhiyuan; Zeng, Caihong; Liu, Zhihong; Zen, Ke; Liu, Yuan

Shi, Lei; Bian, Zhen; Chen, Celia X J; Guo, Ya-Nan; Lv, Zhiyuan; Zeng, Caihong; Liu, Zhihong; Zen, Ke; Liu, Yuan.

Afiliação

Shi L; State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Centre for MicroRNA Biology and Biotechnology, Nanjing University School of Life Sciences, Peoples Republic of China.
Bian Z; Center for Diagnostics and Therapeutics, Center for Inflammation, Immunity and Infection, Department of Biology, Georgia State University, Atlanta, GA, USA.
Chen CX; State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Centre for MicroRNA Biology and Biotechnology, Nanjing University School of Life Sciences, Peoples Republic of China.
Guo YN; Center for Diagnostics and Therapeutics, Center for Inflammation, Immunity and Infection, Department of Biology, Georgia State University, Atlanta, GA, USA.
Lv Z; Center for Diagnostics and Therapeutics, Center for Inflammation, Immunity and Infection, Department of Biology, Georgia State University, Atlanta, GA, USA.
Zeng C; Center for Diagnostics and Therapeutics, Center for Inflammation, Immunity and Infection, Department of Biology, Georgia State University, Atlanta, GA, USA.
Liu Z; Center for Diagnostics and Therapeutics, Center for Inflammation, Immunity and Infection, Department of Biology, Georgia State University, Atlanta, GA, USA.
Zen K; National Clinical Research Centre for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, People's Republic of China.
Liu Y; National Clinical Research Centre for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, People's Republic of China.

J Pathol ; 237(3): 285-95, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26095930

Assuntos

Anticorpos Antinucleares/biossíntese; Antígeno CD47/metabolismo; Imunoglobulina G/biossíntese; Glomérulos Renais/metabolismo; Nefrite Lúpica/prevenção & controle; Receptor fas/deficiência; Animais; Anticorpos Antinucleares/sangue; Anticorpos Antinucleares/imunologia; Antígeno CD47/genética; Antígeno CD47/imunologia; Proliferação de Células; Proteínas do Sistema Complemento/imunologia; Proteínas do Sistema Complemento/metabolismo; Modelos Animais de Doenças; Imunoglobulina G/sangue; Imunoglobulina G/imunologia; Glomérulos Renais/imunologia; Glomérulos Renais/patologia; Nefrite Lúpica/genética; Nefrite Lúpica/imunologia; Nefrite Lúpica/metabolismo; Nefrite Lúpica/patologia; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteinúria/genética; Proteinúria/imunologia; Proteinúria/metabolismo; Proteinúria/prevenção & controle; Esplenomegalia/genética; Esplenomegalia/imunologia; Esplenomegalia/metabolismo; Esplenomegalia/prevenção & controle; Linfócitos T Auxiliares-Indutores/imunologia; Linfócitos T Auxiliares-Indutores/metabolismo; Fatores de Tempo; Receptor fas/genética; Receptor fas/imunologia

Palavras-chave

CD47; T follicular cell; antibody production; autoimmunity

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Nefrite Lúpica / Imunoglobulina G / Anticorpos Antinucleares / Receptor fas / Antígeno CD47 / Glomérulos Renais Tipo de estudo: Prognostic_studies Idioma: En Revista: J Pathol Ano de publicação: 2015 Tipo de documento: Article

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