The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence.
Nat Rev Cancer
; 15(7): 409-25, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26105538
ABSTRACT
Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focused on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes that are induced in the tumour microenvironment by irradiation and discuss how these changes may promote radioresistance and tumour recurrence. We also highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Tipos_de_cancer
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Outros_tipos
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Tratamento
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Radioterapia
Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
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Microambiente Tumoral
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Recidiva Local de Neoplasia
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Nat Rev Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido