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Alternative Wnt Signaling Activates YAP/TAZ.
Park, Hyun Woo; Kim, Young Chul; Yu, Bo; Moroishi, Toshiro; Mo, Jung-Soon; Plouffe, Steven W; Meng, Zhipeng; Lin, Kimberly C; Yu, Fa-Xing; Alexander, Caroline M; Wang, Cun-Yu; Guan, Kun-Liang.
Afiliação
  • Park HW; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
  • Kim YC; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Department of Cardiology, Veterans Medical Research Foundation, San Diego, CA 92161, USA.
  • Yu B; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Moroishi T; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
  • Mo JS; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
  • Plouffe SW; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
  • Meng Z; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
  • Lin KC; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
  • Yu FX; Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
  • Alexander CM; McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53706, USA.
  • Wang CY; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Guan KL; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: kuguan@ucsd.edu.
Cell ; 162(4): 780-94, 2015 Aug 13.
Article em En | MEDLINE | ID: mdl-26276632
The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/ß-catenin signaling. Mechanistically, we delineate the "alternative Wnt-YAP/TAZ signaling axis" that consists of Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. YAP/TAZ mediate the biological functions of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/ß-catenin signaling. Together, our work establishes YAP/TAZ as critical mediators of alternative Wnt signaling.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Proteínas Adaptadoras de Transdução de Sinal / Via de Sinalização Wnt Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Proteínas Adaptadoras de Transdução de Sinal / Via de Sinalização Wnt Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos