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6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
Wang, Lei; Wallace, Adrianne; Raghavan, Sudhir; Deis, Siobhan M; Wilson, Mike R; Yang, Si; Polin, Lisa; White, Kathryn; Kushner, Juiwanna; Orr, Steven; George, Christina; O'Connor, Carrie; Hou, Zhanjun; Mitchell-Ryan, Shermaine; Dann, Charles E; Matherly, Larry H; Gangjee, Aleem.
Afiliação
  • Wang L; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
  • Wallace A; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • Raghavan S; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
  • Deis SM; Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.
  • Wilson MR; Department of Oncology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
  • Yang S; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
  • Polin L; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • White K; Department of Oncology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
  • Kushner J; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • Orr S; Department of Oncology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
  • George C; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • O'Connor C; Department of Oncology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
  • Hou Z; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • Mitchell-Ryan S; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • Dann CE; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • Matherly LH; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute , 110 East Warren Avenue, Detroit, Michigan 48201, United States.
  • Gangjee A; Department of Oncology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
J Med Chem ; 58(17): 6938-59, 2015 Sep 10.
Article em En | MEDLINE | ID: mdl-26317331
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Tiofenos / Receptor 1 de Folato / Transportador de Folato Acoplado a Próton / Antagonistas do Ácido Fólico / Antineoplásicos Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Tiofenos / Receptor 1 de Folato / Transportador de Folato Acoplado a Próton / Antagonistas do Ácido Fólico / Antineoplásicos Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos