Convection-enhanced delivery of SN-38-loaded polymeric micelles (NK012) enables consistent distribution of SN-38 and is effective against rodent intracranial brain tumor models.

Zhang, Rong; Saito, Ryuta; Mano, Yui; Sumiyoshi, Akira; Kanamori, Masayuki; Sonoda, Yukihiko; Kawashima, Ryuta; Tominaga, Teiji

Zhang, Rong; Saito, Ryuta; Mano, Yui; Sumiyoshi, Akira; Kanamori, Masayuki; Sonoda, Yukihiko; Kawashima, Ryuta; Tominaga, Teiji.

Afiliação

Zhang R; a Department of Neurosurgery , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan and.
Saito R; a Department of Neurosurgery , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan and.
Mano Y; a Department of Neurosurgery , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan and.
Sumiyoshi A; b Department of Functional Brain Imaging , Institute of Development, Aging and Cancer, Tohoku University , Sendai , Miyagi , Japan.
Kanamori M; a Department of Neurosurgery , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan and.
Sonoda Y; a Department of Neurosurgery , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan and.
Kawashima R; b Department of Functional Brain Imaging , Institute of Development, Aging and Cancer, Tohoku University , Sendai , Miyagi , Japan.
Tominaga T; a Department of Neurosurgery , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan and.

Drug Deliv ; 23(8): 2780-2786, 2016 Oct.

Article em En | MEDLINE | ID: mdl-26330269

Assuntos

Neoplasias Encefálicas/tratamento farmacológico; Encéfalo/efeitos dos fármacos; Camptotecina/análogos & derivados; Animais; Camptotecina/administração & dosagem; Camptotecina/química; Linhagem Celular Tumoral; Convecção; Sistemas de Liberação de Medicamentos/métodos; Gadolínio/química; Glioma/tratamento farmacológico; Humanos; Irinotecano; Masculino; Camundongos; Micelas; Polímeros/química; Ratos; Ratos Endogâmicos F344; Ratos Nus

Palavras-chave

Chemotherapy; SN-38; convection-enhanced delivery; malignant glioma; micelle

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Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Encéfalo / Neoplasias Encefálicas / Camptotecina Limite: Animals / Humans / Male Idioma: En Revista: Drug Deliv Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2016 Tipo de documento: Article

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