Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation.

Tropberger, Philipp; Mercier, Alexandre; Robinson, Margaret; Zhong, Weidong; Ganem, Don E; Holdorf, Meghan

Tropberger, Philipp; Mercier, Alexandre; Robinson, Margaret; Zhong, Weidong; Ganem, Don E; Holdorf, Meghan.

Afiliação

Tropberger P; Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, CA 94608 don.ganem@novartis.com philipp.tropberger@novartis.com.
Mercier A; Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, CA 94608.
Robinson M; Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, CA 94608.
Zhong W; Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, CA 94608.
Ganem DE; Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, CA 94608 don.ganem@novartis.com philipp.tropberger@novartis.com.
Holdorf M; Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, CA 94608.

Proc Natl Acad Sci U S A ; 112(42): E5715-24, 2015 Oct 20.

Article em En | MEDLINE | ID: mdl-26438841

Assuntos

Cromatina/metabolismo; DNA Viral/genética; Epigênese Genética; Vírus da Hepatite B/genética; Histonas/metabolismo; Plasmídeos/metabolismo; Células Hep G2; Humanos; Transcrição Gênica

Palavras-chave

HBV; cccDNA; chromatin; epigenetics; hepatitis B virus

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Plasmídeos / DNA Viral / Cromatina / Histonas / Vírus da Hepatite B / Epigênese Genética Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article

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